Isotretinoin is a retinoic acid that is all trans retinoic acid in which the double bond which is alphabeta to the carboxy group is isomerised to z configuration a synthetic retinoid it is used for the treatment of severe cases of acne and other skin diseases it has a role as a keratolytic drug an antineoplastic agent and a teratogenic agent. Gain of function mutations in fibroblast growth factor receptor 3 fgfr3 result in achondroplasia for which there is currently no treatment kimura et al show that a previously developed fgf2 targeting rna aptamer prevented fgf2 from activating fgfr3 in rat chondrocytes and mouse tibia organ cultures thereby restoring the chondrocyte proliferation and differentiation required for bone
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